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Related Experiment Video

Updated: Feb 11, 2026

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Roles of PDE1 in Pathological Cardiac Remodeling and Dysfunction.

Si Chen1,2, Walter E Knight3, Chen Yan4

  • 1Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14641, USA. si_chen@urmc.rochester.edu.

Journal of Cardiovascular Development and Disease
|April 26, 2018
PubMed
Summary

Inhibiting phosphodiesterase 1 (PDE1) offers a protective effect against pathological cardiac hypertrophy and dysfunction. This finding highlights PDE1 as a promising therapeutic target for heart failure treatment.

Keywords:
PDE1cardiac dysfunctioncardiac hypertrophycyclic nucleotidephosphodiesterases (PDEs)

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Area of Science:

  • Cardiovascular Science
  • Molecular Biology
  • Pharmacology

Background:

  • Pathological cardiac hypertrophy and dysfunction arise from stress, leading to heart failure.
  • Cyclic nucleotide signaling is crucial for cardiac functions like contractility and remodeling.
  • Cyclic nucleotide phosphodiesterases (PDEs) regulate this signaling and are potential drug targets.

Purpose of the Study:

  • To review recent findings on the role of PDE1 in cardiac function.
  • To elucidate the therapeutic potential of targeting PDE1 in cardiac diseases.

Main Methods:

  • Literature review of recent studies on PDE1 in the cardiac system.
  • Analysis of cyclic nucleotide signaling pathways modulated by PDE1 inhibition.

Main Results:

  • PDE1 inhibition demonstrates a protective role in pathological cardiac remodeling.
  • Modulation of distinct cyclic nucleotide signaling pathways by PDE1 contributes to its cardioprotective effects.

Conclusions:

  • PDE1 plays a significant role in cardiac homeostasis and disease.
  • Targeting PDE1 presents a viable therapeutic strategy for treating cardiac hypertrophy and dysfunction.