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Hypercapnia does not shorten emergence time from propofol anesthesia: a pilot randomized clinical study
Ki-Hyug Kwon1, Hansu Bae1, Hyun Gu Kang1
1Department of Anesthesiology and Pain Medicine, Dongguk University Ilsan Hospital, Goyang, Korea.
Korean Journal of Anesthesiology
|April 26, 2018
Summary
Hypercapnia did not shorten emergence time from propofol anesthesia. Females recovered faster than males, irrespective of carbon dioxide levels during general anesthesia emergence.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Anesthetic agent elimination is critical for emergence from general anesthesia.
- This pilot study investigated hypercapnia's effect on propofol emergence time.
Purpose of the Study:
- To determine if controlled hypercapnia (50 mmHg end-tidal CO2) decreases emergence time from propofol anesthesia compared to hypocapnia (30 mmHg).
- To assess the impact of hypercapnia on key emergence parameters like eye opening.
Main Methods:
- 32 patients were randomized into hypocapnia (30 mmHg) and hypercapnia (50 mmHg) groups.
- Propofol and remifentanil infusions were used to maintain a bispectral index of 40-50.
- Emergence times (spontaneous respiration, eye opening, mouth opening, extubation) were recorded.
Main Results:
- No significant difference in time to eye opening between hypocapnia (9.7 min) and hypercapnia (9.0 min) groups (P=0.688).
- Females demonstrated a significantly faster eye-opening recovery time (3.6 min faster) than males (P=0.009).
Conclusions:
- Hypercapnia did not accelerate emergence from propofol anesthesia in this study.
- Female patients exhibited faster recovery times independent of hypercapnic conditions.
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