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Low expression of c-Myc protein predicts poor outcomes in patients with hepatocellular carcinoma after resection

Fei Ji1, Zhi-Heng Zhang2, Yi Zhang3

  • 1Pediatric Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China.

BMC Cancer
|April 26, 2018
PubMed
Abstract

Insights

Low c-Myc expression indicates poor prognosis in hepatocellular carcinoma (HCC) patients undergoing hepatectomy. Combining c-Myc, TGF-β1, and Embryonic Liver Fodrin (ELF) levels improves outcome prediction for HCC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Hepatology

Background:

  • Embryonic Liver Fodrin (ELF) is crucial for TGF-β signaling, and its disruption compromises this pathway.
  • Disrupted TGF-β signaling, particularly involving Smad3 and Smad4, contributes to hepatocellular carcinoma (HCC) development.
  • The oncogenic transcription factor c-Myc plays a role in HCC, but its prognostic significance requires further investigation.

Purpose of the Study:

  • To investigate the prognostic significance of c-Myc in HCC.
  • To evaluate the combined predictive value of c-Myc, TGF-β1, and ELF in HCC patient outcomes.

Main Methods:

  • Measured c-Myc protein and mRNA expression using immunohistochemistry (IHC) and qRT-PCR.
  • Assessed TGF-β1 and ELF expression in HCC tissues via IHC.
  • Correlated marker expression with clinicopathological factors, overall survival (OS), and disease-free survival (DFS).

Main Results:

  • c-Myc expression was significantly higher in HCC tissues compared to normal liver tissues.
  • Low c-Myc expression independently predicted shorter DFS and OS, and correlated with smaller tumor size, fewer tumors, and less recurrence.
  • Combined analysis of c-Myc, TGF-β1, and ELF demonstrated superior predictive value for patient outcomes compared to individual markers.

Conclusions:

  • Low c-Myc protein expression is a predictor of poor outcomes in HCC patients post-hepatectomy.
  • A combination of c-Myc, TGF-β1, and ELF expression levels can accurately predict HCC patient prognosis.
Keywords:
BiomarkersC-MYCHepatocellular carcinomaOncogenePrognosis

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