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[SIN-1 in intracoronary administration].

W Schulz

    Presse Medicale (Paris, France : 1983)
    |May 25, 1988
    PubMed
    Summary

    SIN-1, a novel anti-anginal drug, effectively dilates coronary arteries without causing blood steal, offering a prolonged effect superior to nitroglycerin. It is indicated for coronary arteriography and spasms due to its specific action and favorable side-effect profile.

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    Area of Science:

    • Cardiovascular pharmacology
    • Interventional cardiology

    Background:

    • SIN-1 is a novel anti-anginal compound.
    • Extensive clinical and experimental research has been conducted on SIN-1.

    Purpose of the Study:

    • To evaluate the effects of SIN-1 on coronary circulation.
    • To compare SIN-1's efficacy and safety with existing anti-anginal agents.

    Main Methods:

    • SIN-1 was administered via direct injection into coronary arteries in over 1,000 patients.
    • Hemodynamic parameters were assessed to understand SIN-1's systemic effects.

    Main Results:

    • SIN-1 demonstrated rapid and prolonged dilation of epicardial coronary vessels without inducing blood steal.
    • Its vasodilatory effect is comparable to nitroglycerin and calcium channel blockers but lasts longer.
    • SIN-1 reduced preload significantly with minimal impact on afterload, contractility, or peripheral resistance.
    • Effective in relieving coronary spasm and improving anterograde and collateral circulation.

    Conclusions:

    • SIN-1 is a potent vasodilator for epicardial coronary arteries.
    • Its unique properties make it suitable for coronary arteriography and managing coronary spasms.
    • SIN-1 presents a favorable hemodynamic profile with minimal side effects.

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