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Updated: Feb 11, 2026
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Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
Published on: March 14, 2019
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[Treatment of vancomycin-resistant enterococcal infections]
Lars Christian Lund1, Barbara Juliane Holzknecht, Ulrik Stenz Justesen
1lcl@posteo.dk.
Ugeskrift for Laeger
|April 26, 2018
Summary
Vancomycin-resistant enterococci (VRE) infections are rising in Denmark, with limited treatment guidelines. Current options include ciprofloxacin or nitrofurantoin for urinary tract infections, and linezolid or daptomycin for severe VRE infections.
Area of Science:
- Infectious Diseases
- Microbiology
- Clinical Pharmacy
Background:
- Vancomycin-resistant enterococci (VRE) pose a significant and increasing healthcare challenge.
- VRE incidence in Denmark has risen eightfold since 2012.
- There is a lack of specific Danish national guidelines for managing VRE infections.
Purpose of the Study:
- To review and summarize current treatment strategies for Vancomycin-resistant enterococci (VRE) infections.
- To address the scarcity of treatment options for ampicillin-resistant VRE.
- To provide guidance in the absence of established Danish national protocols.
Main Methods:
- Literature review of existing treatment guidelines and clinical studies.
- Analysis of antimicrobial susceptibility patterns and treatment outcomes.
- Synthesis of evidence for uncomplicated and complicated VRE infections.
Main Results:
- Ciprofloxacin or nitrofurantoin are recommended for uncomplicated VRE urinary tract infections.
- Linezolid or high-dose daptomycin are the primary treatments for VRE bacteraemia and severe infections.
- Combination therapy is advised for complicated VRE infections or extended treatment durations.
Conclusions:
- Effective management of VRE infections requires careful selection of antimicrobial agents based on infection severity and type.
- The increasing incidence of VRE necessitates updated clinical guidelines and treatment strategies.
- Further research and guideline development are crucial for optimal patient care.
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