Related Experiment Video

Updated: Feb 11, 2026

Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment
06:48

Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment

Published on: June 25, 2019

9.8K

Mild cognitive impairment is associated with poor physical function but not bone structure or density in late

A Patel1,2, K A Jameson2, M H Edwards2

  • 1University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Archives of Osteoporosis
|April 26, 2018
PubMed

Insights

Mild cognitive impairment (MCI) in older adults is linked to reduced physical performance. However, this cognitive decline does not appear to affect bone density or structure.

Area of Science:

  • Gerontology
  • Neuroscience
  • Orthopedics

Background:

  • Mild cognitive impairment (MCI) is a growing concern in aging populations.
  • Understanding the relationship between cognitive health and physical well-being is crucial for maintaining quality of life in older adults.
  • Previous research has explored links between cognitive function and various health outcomes, but the specific associations with physical function and bone health require further elucidation.

Purpose of the Study:

  • To investigate the association between mild cognitive impairment (MCI) and physical performance in community-dwelling older adults.
  • To examine the relationship between MCI and bone health, including bone mineral density, strength, and microarchitecture.
  • To differentiate the impact of cognitive status on physical function versus skeletal health in an aging cohort.

Main Methods:

  • A cross-sectional study involving 443 community-dwelling older adults (mean age ~75.6 years).
  • Cognitive function was assessed using the Strawbridge questionnaire and the Mini Mental State Exam (MMSE).
  • Physical function was evaluated through a physical performance score, while bone health was assessed using DXA, pQCT, and HR-pQCT.

Main Results:

  • Mild cognitive impairment (MCI), particularly when defined by MMSE score < 24, was significantly associated with poorer physical performance in men.
  • Higher MMSE scores correlated with better physical performance in both sexes.
  • No significant association was found between cognitive impairment (by either measure) and bone density, shape, or microarchitecture in either men or women.

Conclusions:

  • Mild cognitive impairment (MCI) in older adults is associated with diminished physical performance.
  • Cognitive status does not appear to influence bone mineral density, shape, or microarchitecture in this cohort.
  • These findings highlight the impact of cognitive decline on physical function, suggesting potential targets for intervention in geriatric care.
Keywords:
Bone parametersEpidemiologyMild cognitive impairmentPhysical performance

More Related Videos

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

8.1K
Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment05:58

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment

Published on: March 11, 2021

5.1K

Related Concept Videos

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
904
Piaget's Theory of Cognitive Development from Childhood into Adulthood01:25

Piaget's Theory of Cognitive Development from Childhood into Adulthood

Jean Piaget's theory of cognitive development emphasizes the role of thinking in a child's learning process, suggesting that children are naturally curious about their environment. His approach to development is discontinuous, proposing that cognitive abilities progress through distinct stages, each with unique characteristics. Central to Piaget's theory is schemata—mental structures that allow individuals to understand and interpret the world.
Schemata: Building Blocks of Knowledge
1.7K
Structural Protein Function01:56

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
30.0K
Cognitive Dissonance01:38

Cognitive Dissonance

Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
37.5K
Theory of Romantic Attachment in Adulthood03:34

Theory of Romantic Attachment in Adulthood

Attachment is a long-standing connection or bond with others. While Attachment Theory was conceived in developmental psychology to describe infant-caregiver bonding, it's been extended into adulthood to include romantic relationships. 
50.0K
Bone Structure01:55

Bone Structure

Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.9K