Related Experiment Video
Updated: Feb 11, 2026
07:32
Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
5.6K
Microbiota transplantation: concept, methodology and strategy for its modernization
Faming Zhang1,2,3, Bota Cui4,5, Xingxiang He6
1Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China. fzhang@njmu.edu.cn.
Protein & Cell
|April 26, 2018
Summary
Fecal microbiota transplantation (FMT) is a key research area for treating various diseases by modulating the gut microbiome. This review covers FMT evolution, methods, and future strategies for standardized microbial therapies.
Area of Science:
- Microbiology
- Gastroenterology
- Translational Medicine
Background:
- Fecal microbiota transplantation (FMT) is gaining attention for its role in treating diverse diseases.
- Microbiota-host interactions are implicated in conditions like Clostridium difficile infection, IBD, diabetes, cancer, and gut-brain disorders.
Purpose of the Study:
- To review the historical and current concepts of microbiota transplantation.
- To discuss the evolution from FMT to selective microbiota transplantation.
- To explore FMT methodology development and step-up strategies.
Main Methods:
- Literature review of microbiota transplantation studies.
- Analysis of expert perspectives on FMT.
- Examination of historical and modern approaches to microbial therapies.
Main Results:
- FMT has shown clinical efficacy across a spectrum of diseases.
- The concept of microbiota transplantation has evolved significantly.
- Standardized FMT strategies are crucial for future clinical application.
Conclusions:
- Microbiota transplantation holds promise for treating numerous human diseases.
- Advancements in FMT methodology and strategic approaches are essential.
- Further research into standardized microbiota transplantation will improve therapeutic outcomes.
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