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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Accelerators in concrete serve as admixtures to speed up the hardening process, enabling the concrete to achieve early strength faster. Although accelerators do not necessarily impact the time it takes concrete to set, they reduce this time in practice. A common accelerator is calcium chloride, which is particularly useful for hastening early strength development in cold weather or for rapid repair jobs that require quick heat generation after mixing.
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Average Acceleration01:30

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The importance of understanding acceleration spans our day-to-day experiences, as well as the vast reaches of outer space and the tiny world of subatomic physics. In everyday conversation, to accelerate means to speed up. For instance, we are familiar with the acceleration of our car; the harder we apply our foot to the gas pedal, the faster we accelerate. The greater the acceleration, the greater the change in velocity over a given time. Acceleration is widely seen in experimental physics. In...
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Acceleration is in the direction of the change in velocity, but it is not always in the direction of motion. When an object slows down, its acceleration is opposite to the direction of its motion. Although commonly referred to as deceleration, this causes confusion in our analysis as deceleration is not a vector, and does not point to a specific direction with respect to a coordinate system. Therefore, the term deceleration is not used. For example, when a subway train slows down, it...
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In everyday conversation, accelerating means speeding up. Acceleration is a vector in the same direction as the change in velocity, Δv, therefore the greater the acceleration, the greater the change in velocity over a given time. Since velocity is a vector, it can change in magnitude, direction, or both. Thus acceleration is a change in speed or direction, or both. For example, if a runner traveling at 10 km/h due east slows to a stop, reverses direction, and continues their run at 10 km/h...
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When a fluid is in constant acceleration, the pressure and buoyant force equations are modified. Suppose a beaker is placed in an elevator accelerating upward with a constant acceleration, a. In the beaker, assume there is a thin cylinder of height h with an infinitesimal cross-sectional area, ΔS.
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Basics of Multivariate Analysis in Neuroimaging Data
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GPU Accelerated Browser for Neuroimaging Genomics.

Bob Zigon1, Huang Li2, Xiaohui Yao3

  • 1Beckman Coulter, Indianapolis, IN, 46268, USA. robert.zigon@beckman.com.

Neuroinformatics
|April 26, 2018
PubMed
Summary
This summary is machine-generated.

This study introduces a GPU-accelerated tool for neuroimaging genomics big data analysis. It significantly speeds up analysis of single nucleotide polymorphism (SNP) and gene-based data for researchers.

Keywords:
Alzheimer’s diseaseData miningGPUGenomicsMRIVersatile gene based association study

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Area of Science:

  • Neuroimaging Genomics
  • Computational Neuroscience
  • Bioinformatics

Background:

  • Neuroimaging genomics aims to link brain structure/function to genetic variations.
  • Large-scale imaging and genomics data present significant computational challenges.
  • Current analytical methods struggle with the scale of big data in this field.

Purpose of the Study:

  • To develop an interactive visual exploratory system for mining big data in neuroimaging genomics.
  • To overcome computational bottlenecks in analyzing large neuroimaging genomics datasets.
  • To enable researchers to efficiently explore complex genetic and imaging data.

Main Methods:

  • Developed a GPU-accelerated browsing tool for neuroimaging genomics.
  • Implemented the ANOVA algorithm for single nucleotide polymorphism (SNP) based analysis.
  • Integrated the VEGAS algorithm for gene-based analysis, both at interactive rates.

Main Results:

  • The GPU-accelerated ANOVA algorithm is 110x faster than its 4-core OpenMP counterpart.
  • The GPU-accelerated VEGAS algorithm is 375x faster than its 4-core OpenMP counterpart.
  • Achieved interactive rates for complex data mining tasks.

Conclusions:

  • The developed system provides a foundational approach for interactive visual exploration of large-scale imaging genomics datasets.
  • GPU acceleration significantly enhances the speed and efficiency of neuroimaging genomics analyses.
  • This work facilitates deeper understanding of the genetic basis of brain structure and function.