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Updated: Feb 11, 2026

Preterm EEG: A Multimodal Neurophysiological Protocol
19:32

Preterm EEG: A Multimodal Neurophysiological Protocol

Published on: February 18, 2012

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Early postnatal growth and neurodevelopment in children born moderately preterm or small for gestational age at term:

Marion Taine1,2,3, Marie-Aline Charles1,2, Jacques Beltrand2,3,4

  • 1Early Determinants of Children's Health and Development Team (ORCHAD), Inserm UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Villejuif, France.

Paediatric and Perinatal Epidemiology
|April 26, 2018
PubMed

Insights

Early postnatal growth positively impacts neurodevelopment in preterm infants and those small for gestational age. This review highlights the critical first six months for cognitive outcomes like IQ, suggesting a potential ceiling effect.

Area of Science:

  • Developmental Pediatrics
  • Neonatology
  • Neuroscience

Background:

  • Growing clinical interest in long-term effects of early postnatal growth (EPG).
  • Established link between rapid EPG and cardiovascular risk.
  • Hypothesized neurodevelopmental benefits of EPG in moderately preterm (MP) and small for gestational at term (SGAT) infants remain under-explored.

Purpose of the Study:

  • To systematically review the relationship between EPG (before age 3 years) and neurodevelopmental outcomes.
  • Focus on individuals born MP (32-36 weeks' GA) or SGAT.
  • Adherence to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines.

Main Methods:

  • Systematic literature search of Web of Science, EMBASE, and PubMed (inception to July 1, 2017).
  • Inclusion of 19 articles from 12 distinct study populations.
  • Quality assessment using a detailed scale; meta-analysis precluded by lack of standardized growth analysis.

Main Results:

  • A positive association observed between EPG and neurodevelopmental outcomes, particularly Intelligence Quotient (IQ).
  • The first six months of life identified as a potentially critical period.
  • Non-linear association noted, with a plateau in IQ suggesting a possible ceiling effect for higher weight gain.

Conclusions:

  • Generally positive association found between EPG and neurodevelopmental outcomes for MP and SGAT infants.
  • Highlights the importance of early growth for cognitive development in vulnerable populations.
  • Recommends strategies for future epidemiological studies to refine understanding of this relationship.
Abstract

Keywords:
body sizecatch uphead circumferenceintrauterine growth restrictionneurodevelopmental disordersprematurity

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