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Updated: Feb 11, 2026

Multimodal 3D Printing of Phantoms to Simulate Biological Tissue
Published on: January 11, 2020
3D Printed Functional and Biological Materials on Moving Freeform Surfaces
Zhijie Zhu1, Shuang-Zhuang Guo1, Tessa Hirdler2
1Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.
Adaptive 3D printing uses real-time feedback and computer vision to print electronics and hydrogels on moving surfaces, including a human hand and live mice. This innovation enables smart manufacturing for wearable devices and advanced medical treatments.
Area of Science:
- Robotics and Automation
- Materials Science and Engineering
- Biomedical Engineering
Background:
- Conventional 3D printing relies on static, open-loop systems requiring pre-calibration.
- Fabrication on dynamic or freeform surfaces presents significant challenges for traditional methods.
- Need for advanced manufacturing techniques capable of real-time adaptation.
Purpose of the Study:
- To introduce and demonstrate adaptive 3D printing as a closed-loop fabrication method.
- To enable the creation of functional devices on moving, freeform surfaces.
- To explore applications in wearable electronics and biomedical treatments.
Main Methods:
- Integration of a robotic system with computer vision for real-time workspace perception.
- Closed-loop control combining direct ink writing with feedback.
- Hybrid fabrication: 3D printing of electrical connections and automated component placement.
- Application of adaptive printing on free-moving human hands and live mice.
Main Results:
- Successful fabrication of functional electronic devices on a moving human hand.
- Demonstration of printing cell-laden hydrogels on live mice for wound healing models.
- Validation of adaptive 3D printing's capability to handle dynamic geometries and motions.
Conclusions:
- Adaptive 3D printing offers a novel approach for fabricating complex devices on unconventional surfaces.
- This technology has potential for on-body wearable electronics and advanced regenerative medicine.
- Opens new avenues for smart manufacturing and personalized medical interventions.
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