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Hidradenitis Suppurativa: Inside and Out.

Sharmila Patil1, Astuty Apurwa1, Nitin Nadkarni1

  • 1Department of Dermatology, Dr. D. Y. Patil Hospital, Navi Mumbai, Maharashtra, India.

Indian Journal of Dermatology
|April 26, 2018
PubMed
Summary

Hidradenitis suppurativa is a chronic skin condition causing painful nodules and sinuses. Effective management involves lifestyle changes, topical treatments, antibiotics, biologics, and surgery for severe cases.

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Area of Science:

  • Dermatology
  • Immunology

Background:

  • Hidradenitis suppurativa (HS) is a chronic, disabling skin disease affecting apocrine gland areas.
  • It primarily impacts individuals in their early 20s, with a higher prevalence in women.
  • Estimated disease prevalence ranges from 1-4% globally.

Purpose of the Study:

  • To provide a comprehensive overview of hidradenitis suppurativa.
  • To discuss the etiology, risk factors, and associated comorbidities of HS.
  • To outline current and emerging treatment strategies for HS.

Main Methods:

  • Literature review of hidradenitis suppurativa.
  • Analysis of disease characteristics, risk factors, and comorbidities.
  • Evaluation of treatment modalities including conservative, medical, and surgical options.
Keywords:
Acne inversaHurley's stagingSartorius systemTapocrine glandacne triadadalimumabhidradenitis suppurativametformin

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Main Results:

  • HS is linked to follicular abnormalities and risk factors like smoking, obesity, and genetics.
  • Comorbidities include inflammatory bowel disease and pyoderma gangrenosum.
  • Topical antibiotics, oral antibiotics, biologics, and surgery are key treatment components.

Conclusions:

  • Management requires a multi-faceted approach addressing lifestyle and medical interventions.
  • Biologics represent a promising treatment avenue for moderate to severe HS.
  • Early diagnosis and comprehensive care are crucial for improving patient outcomes.