Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tolerance of spironolactone.

B R Hughes1, W J Cunliffe

  • 1Department of Dermatology, General Infirmary, Leeds, U.K.

The British Journal of Dermatology
|May 1, 1988
PubMed
Summary

Spironolactone effectively treats hirsutism and acne, but most patients experience side effects, often manageable with dose adjustments or combined oral contraceptives. Regular monitoring is advised, especially early in treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Suspension of marketing authorization for ingenol mebutate.

The British journal of dermatology·2020
Same author

Impact of smoking on imiquimod response in patients with vulval intraepithelial neoplasia.

Clinical and experimental dermatology·2019
Same author

British Association of Dermatologists' guidelines for the care of patients with actinic keratosis 2017.

The British journal of dermatology·2017
Same author

Segmental cherry angiomas associated with extragenital lichen sclerosus: a report of two cases.

Clinical and experimental dermatology·2013
Same author

Progressive chronic nasal enlargement with an overlying violaceous plaque.

Clinical and experimental dermatology·2009
Same author

A relationship between perioperative blood transfusion and recurrence of carcinoma of the sigmoid colon following potentially curative surgery.

Annals of the Royal College of Surgeons of England·2009

Area of Science:

  • Dermatology
  • Endocrinology

Background:

  • Spironolactone is prescribed for hirsutism and acne.
  • Its anti-androgenic mechanism can cause side effects.

Purpose of the Study:

  • To survey side effects of spironolactone in patients with hirsutism or acne.
  • To assess management strategies for spironolactone-induced side effects.

Main Methods:

  • Survey of 54 patients undergoing spironolactone treatment.
  • Analysis of reported side effects and their management.

Main Results:

  • 91% of patients experienced side effects, primarily anti-androgenic (80%).
  • Concomitant contraceptive pill use reduced menstrual abnormalities.
  • Dose reduction (125-175 mg daily) managed side effects in 8 patients.
Keywords:
AcneAndrogensBiologyContraceptionContraceptive MethodsDemographic FactorsDermatitisDermatological EffectsDiseasesEndocrine SystemEnzyme Inhibitors--side effectsEnzymes And Enzyme InhibitorsFamily PlanningHirsutismHormone AntagonistsHormonesMelanosisMelasmaMenstruation DisordersOral ContraceptivesPhysiologyPopulationPopulation CharacteristicsSex FactorsSigns And SymptomsTreatment--side effects

Related Experiment Videos

  • Two patients developed 'chloasma', a late-onset, unreported side effect.

    • Conclusions:

    • Spironolactone is generally well-tolerated, with most side effects manageable.
    • Early monitoring is crucial for identifying and managing side effects.
    • Chloasma is a potential late-onset complication.