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Updated: Feb 11, 2026

Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection
Published on: June 12, 2014
Entamoeba histolytica: A surprising coexistence with adenocarcinoma - Never brush aside brushings for biopsy
Palvi Goel1, Ruchita Tyagi1, Gursheen Kaur2
1Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
Abstract:
Entamoeba histolytica has been rarely reported as superadded infection over carcinomatous growth on rectal brushings. We present a case of 68-year-old male who presented with abdominal pain and bleeding per rectum who was found to have an ulceroproliferative growth on sigmoidoscopy. Rectal brushings revealed coexistence of E. histolytica with malignant cells of adenocarcinoma. No organism was detected on biopsy of the tumor, which also showed adenocarcinoma, because of possible surface colonization of the tumor by Entamoeba. This case highlights the role of rectal brushings in detecting superadded infection in a case where both brushings and biopsy were performed. It is always important to report infection superadded on malignancies for optimum management of the patients.
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