Precisely printable and biocompatible silk fibroin bioink for digital light processing 3D printing
Soon Hee Kim1, Yeung Kyu Yeon1, Jung Min Lee1
1Nano-Bio Regenerative Medical Institute, College of Medicine, Hallym University, Chuncheon, 24252, Republic of Korea.
Nature Communications
|April 26, 2018
Summary
Researchers developed a novel silk fibroin (SF) based bioink, Sil-MA, for digital light processing (DLP) 3D bioprinting. This biocompatible and printable bioink enables the creation of complex organ structures for tissue engineering applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Bioprinting Technology
Background:
- Three-dimensional (3D) bioprinting faces challenges with bioink biocompatibility and printability.
- Silk fibroin (SF) is a promising natural polymer for biomaterial development.
Purpose of the Study:
- To develop a novel silk fibroin-based bioink for digital light processing (DLP) 3D bioprinting.
- To evaluate the printability, mechanical properties, and biocompatibility of the developed bioink for tissue engineering.
Main Methods:
- Silk fibroin (SF) was modified via methacrylation with glycidyl methacrylate (GMA) to create the Sil-MA bioink.
- Mechanical and rheological properties of the Sil-MA hydrogel were characterized.
- DLP 3D bioprinting was used to fabricate complex organ structures.
- Biocompatibility of the printed structures was assessed.
Main Results:
- The Sil-MA bioink exhibited outstanding mechanical and rheological properties, tunable by Sil-MA content.
- Highly complex organ structures (heart, vessel, brain, trachea, ear) were successfully printed with excellent structural stability.
- The Sil-MA bioink demonstrated reliable biocompatibility.
Conclusions:
- The developed Sil-MA bioink is suitable for DLP 3D bioprinting.
- This novel bioink shows significant potential for applications in tissue and organ engineering.
- Sil-MA offers a promising solution to current bioink limitations in 3D bioprinting.
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