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Related Experiment Video

Updated: Feb 11, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

Flocking transitions in confluent tissues.

Fabio Giavazzi¹, Matteo Paoluzzi, Marta Macchi

¹Università degli Studi di Milano, Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, 20090 Segrate, Italy. roberto.cerbino@unimi.it.

|April 26, 2018

Summary

This summary is machine-generated.

Collective cell migration is crucial for development and disease. Aligning cell polarization with movement facilitates collective motion and tissue solidification, explained by statistical physics models.

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Area of Science:

Cell biology
Biophysics
Statistical mechanics

Background:

Collective cell migration is vital for embryonic development, wound healing, and cancer invasion.
Mechanisms of cohesive cell group movement remain poorly understood, unlike single-cell behaviors.

Purpose of the Study:

To elucidate the emergence of collective migration in mechanosensitive cells.
To investigate the role of orientational feedback in confluent tissue dynamics.

Main Methods:

Utilized a self-propelled Voronoi (SPV) model for confluent tissues.
Incorporated orientational feedback aligning cell polarization with local migration velocity.
Extended statistical physics tools (e.g., effective temperature) to a far-from-equilibrium system.

Main Results:

Aligning interactions significantly facilitate collective motion and promote tissue solidification.
Identified density-independent liquid-solid transitions governed by aligning interactions.
Model successfully accounts for experimental observations in epithelial monolayers.

Conclusions:

Aligning cell polarization is a key factor in collective cell migration and tissue solidification.
Statistical physics frameworks can predict transitions in far-from-equilibrium cellular systems.
The model predicts flocking signatures, offering a quantitative approach to collective motility.