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Triboluminescence from Pharmaceutical Formulations.

Casey J Smith1, Scott R Griffin1, Gregory S Eakins1

  • 1Department of Chemistry , Purdue University , 560 Oval Drive , West Lafayette Indiana 47906 , United States.

Analytical Chemistry
|April 26, 2018
PubMed
Summary
This summary is machine-generated.

Triboluminescence (TL) can detect trace crystallinity in amorphous solid dispersions (ASDs). This method offers a sensitive and simple approach for quality control in pharmaceutical formulations.

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Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Pharmaceutical Science

Background:

  • Amorphous solid dispersions (ASDs) are crucial in pharmaceutical formulations.
  • Trace crystallinity in ASDs can compromise physical stability during manufacturing and storage.
  • Sensitive detection methods for trace crystallinity are needed.

Purpose of the Study:

  • To investigate Triboluminescence (TL) as a method for detecting trace crystallinity in ASDs.
  • To establish the sensitivity and applicability of TL for quality control of amorphous materials.

Main Methods:

  • Triboluminescence (TL) measurements were performed on a model ASD (griseofulvin in polyethylene glycol).
  • Studies on particle size dependence (sucrose) and polymorphism (clopidogrel bisulfate) were conducted.
  • The mechanism of TL was explored in relation to piezoelectricity.

Main Results:

  • TL enabled selective detection of trace crystallinity in ASDs.
  • A limit of detection of 140 ppm was achieved for the model ASD.
  • Results suggest TL is linked to the piezoelectric response of crystalline fractions.

Conclusions:

  • Triboluminescence (TL) is a broadly applicable and simple experimental route for sensitive detection of trace crystallinity.
  • TL can be used to monitor the physical stability of amorphous solid dispersions.
  • The piezoelectric properties of crystalline materials are key to TL detection.