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Updated: Feb 11, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Rationale for treating hepatitis C virus infection in patients with mild to moderate chronic kidney disease
Ezequiel Ridruejo1,2,3, Manuel Mendizabal2,3, Marcelo O Silva2,3
1Hepatology Section, Department of Medicine; Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno "CEMIC", Ciudad Autónoma de Buenos Aires, Argentina.
Insights
Treating Hepatitis C virus (HCV) infection in early chronic kidney disease (CKD) stages 2-3 may slow disease progression and improve cardiovascular health. This review examines the benefits of HCV treatment in CKD patients.
Area of Science:
- Nephrology
- Hepatology
- Cardiology
Background:
- Hepatitis C virus (HCV) infection is common in chronic kidney disease (CKD) patients.
- Limited data exists on HCV treatment benefits for CKD stages 2-3.
- Current guidelines vary on prioritizing HCV treatment for these patients.
Purpose of the Study:
- To review evidence on HCV's impact on CKD progression.
- To assess HCV treatment benefits for cardiovascular and metabolic outcomes.
- To focus on HCV treatment advantages in CKD stages 2-3 for slowing disease progression.
Main Methods:
- Literature review of current evidence.
- Evaluation of HCV impact on CKD progression.
- Analysis of cardiovascular and metabolic outcomes post-HCV treatment.
Main Results:
- HCV infection significantly impacts CKD progression.
- HCV treatment can improve cardiovascular and metabolic health.
- Evidence suggests benefits of HCV treatment in early CKD stages.
Conclusions:
- HCV treatment is crucial for managing CKD progression.
- Early HCV treatment improves overall health outcomes in CKD patients.
- Further research is needed to solidify treatment guidelines for CKD stages 2-3.
Abstract:
Hepatitis C virus infection (HCV) is highly prevalent in patients with chronic kidney disease (CKD) and kidney transplant recipients. Little information exists on treatment in patients with CKD stages 2 to 3, where CKD progression might be slowed by HCV treatment. These patients are not considered a high priority for HCV treatment in most international guidelines. Although some recently published guidelines propose universal treatment, others are still recommending it only in high priority groups. In this review, we evaluate current evidence of HCV infection impact on CKD progression, on cardiovascular and metabolic risk, and the benefits of HCV infection treatment to improve cardiovascular and metabolic outcomes. We made special focus on the benefits of HCV infection treatment in patients with stages 2 to 3 CKD to avoid CKD progression.
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Chronic Kidney Disease I: Introduction
Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease III: Interprofessional Care
Chronic Kidney Disease IV: Nursing Management
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Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

