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Customizable cap implants for neurophysiological experimentation.

Jackson D Blonde1, Megan Roussy1, Rogelio Luna1

  • 1Cognitive Neurophysiology Laboratory, Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Robarts Research Institute and the Brain and Mind Institute, Western University, 1151 Richmond St. N., Room 7239, London, ON, N6A 5B7, Canada.

Journal of Neuroscience Methods
|April 26, 2018
PubMed
Summary
This summary is machine-generated.

Custom-fit polyether ether ketone (PEEK) cranial implants offer a stronger, less invasive alternative for primate neurophysiology research. These novel implants reduce complications and optimize skull surface area for extended, high-quality experimentation.

Keywords:
CranialCustomizableElectrophysiologyImplantMacaquePEEK

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Area of Science:

  • Neurosurgery
  • Biomaterials Science
  • Primate Research

Background:

  • Traditional primate cranial implants often use acrylic and screws, leading to complications like infection and failure.
  • Titanium and polyether ether ketone (PEEK) implants offer advantages such as mechanical strength, osseointegration, lightweight properties, and MRI compatibility.
  • Recent custom-fit titanium/PEEK implants have improved outcomes but can be more invasive.

Purpose of the Study:

  • To develop and evaluate novel, custom-fit polyether ether ketone (PEEK) 'cap' implants for primate neurophysiology research.
  • To improve upon existing cranial implant designs by reducing invasiveness and enhancing durability.

Main Methods:

  • Custom PEEK cap implants were designed using MRI/CT data and SolidWorks software.
  • Implants were fabricated using CNC-machining.
  • Surgical implantation and chronic electrophysiological recordings were performed in three rhesus macaques.

Main Results:

  • PEEK cap implants were successfully implanted in rhesus macaques, enabling head fixation and chronic recordings.
  • Design improvements and surgical techniques resolved issues with granulation tissue and headpost screw breakage.
  • The PEEK cap design proved effective in minimizing infection and implant failure.

Conclusions:

  • The novel PEEK cap implants provide an effective, affordable, and less invasive solution for primate electrophysiological experiments.
  • These implants offer increased strength and optimize the usable skull surface area compared to existing methods.
  • The PEEK cap design prolongs experimental duration and maximizes the scientific contribution per primate.