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To Decipher the Mycoplasma hominis Proteins Targeting into the Endoplasmic Reticulum and Their Implications in

Mohammed Zakariah1, Shahanavaj Khan2,3, Anis Ahmad Chaudhary4

  • 1Research Center, College of Computer and Information Science, King Saud University, Riyadh 11451, Saudi Arabia. mzakariah@ksu.edu.sa.

Molecules (Basel, Switzerland)
|April 27, 2018
PubMed

Insights

Mycoplasma hominis infections may contribute to prostate cancer development. This study identified bacterial proteins targeting host cell endoplasmic reticulum, potentially disrupting normal cell function and promoting cancer growth.

Area of Science:

  • Microbiology
  • Oncology
  • Cell Biology

Background:

  • Cancer was historically viewed as a genetic disease.
  • Emerging research links bacterial infections to cancer development.
  • Mycoplasma hominis, an enteroinvasive bacterium, is implicated in prostate cancer growth.

Purpose of the Study:

  • To identify Mycoplasma hominis proteins that target the host cell endoplasmic reticulum (ER).
  • To investigate the potential role of these proteins in prostate cancer induction.

Main Methods:

  • Bioinformatic analysis of the Mycoplasma hominis proteome.
  • Prediction of protein localization to the host cell ER.

Main Results:

  • 19 Mycoplasma hominis proteins were predicted to localize to the host cell ER.
  • These proteins may interfere with normal protein folding within the ER.
  • Alterations in host cell function due to these bacterial proteins are suggested.

Conclusions:

  • Mycoplasma hominis proteins can be targeted to the host cell ER.
  • These proteins may play a role in altering host cell function, potentially contributing to prostate cancer.
  • Intercellular Mycoplasma hominis infection is a potential factor in prostate cancer etiology.
Keywords:
Mycoplasma hominisendoplasmic reticulumprostate cancerprotein targetingsystems biology

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