Related Experiment Video

Updated: Feb 11, 2026

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

9.0K

Targeting GLI Transcription Factors in Cancer

Miroslava Didiasova1, Liliana Schaefer2, Malgorzata Wygrecka3,4

  • 1Department of Biochemistry, Faculty of Medicine, Universities of Giessen and Marburg Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany. miroslava.didiasova@biochemie.med.uni-giessen.de.

Molecules (Basel, Switzerland)
|April 27, 2018
PubMed

Insights

Aberrant hedgehog (Hh) signaling drives cancer, and while SMO inhibitors work initially for basal cell carcinoma (BCC), resistance emerges. Glioma-associated oncogene (GLI) transcription factors are key players in Hh pathway activation and cancer progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Signaling

Background:

  • Aberrant hedgehog (Hh) signaling is implicated in over 25% of human cancer deaths.
  • Smoothened (SMO) inhibitors show initial efficacy in basal cell carcinoma (BCC) but acquired resistance leads to relapse.
  • Non-canonical, SMO-independent Hh pathway activation contributes to therapeutic resistance in BCC.

Purpose of the Study:

  • To review the role of glioma-associated oncogene (GLI) transcription factors in Hh signaling.
  • To explore the involvement of GLI factors in regulating oncogenic signaling pathways.
  • To highlight GLIs as central hubs in tumor signaling networks for anti-cancer therapy development.

Main Methods:

  • Literature review of studies on hedgehog signaling in cancer.
  • Analysis of the downstream effectors of canonical and non-canonical Hh pathways.
  • Investigation of GLI transcription factors' role in tumor signaling.

Main Results:

  • GLI transcription factors are the main downstream effectors of both canonical and non-canonical Hh cascades.
  • GLIs are involved in the regulation of multiple oncogenic signaling pathways.
  • Hh signaling contributes significantly to malignant transformation.

Conclusions:

  • GLI transcription factors are central regulators in tumor signaling networks.
  • GLIs represent attractive molecular targets for novel anti-cancer therapies.
  • Targeting GLIs may overcome resistance mechanisms associated with SMO inhibitors.
Keywords:
GLI inhibitorscancercancer stem cellsglioma-associated oncogene homologhedgehog signaling

More Related Videos

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

3.2K
Enhanced Yeast One-hybrid Screens To Identify Transcription Factor Binding To Human DNA Sequences11:25

Enhanced Yeast One-hybrid Screens To Identify Transcription Factor Binding To Human DNA Sequences

Published on: February 11, 2019

8.5K

Related Concept Videos

Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.9K
Transcription Elongation Factors02:35

Transcription Elongation Factors

Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
14.1K
Transcription Elongation Factors02:35

Transcription Elongation Factors

4.8K
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
7.2K
Transcription01:10

Transcription

Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
157.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K