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Related Experiment Videos

Fundamental science behind today's important medicines.

Jonathan M Spector1, Rosemary S Harrison1, Mark C Fishman2

  • 1Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.

Science Translational Medicine
|April 27, 2018
PubMed
Summary

Fundamental scientific discoveries, initially pursued without practical aims, often lead to transformative medicines decades later. This highlights the long-term value of basic research in medical innovation.

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Area of Science:

  • Biomedical Research
  • Medical Science
  • Drug Discovery

Background:

  • Many groundbreaking medical treatments originate from basic science research.
  • The practical applications of fundamental discoveries may not be immediately apparent.

Purpose of the Study:

  • To underscore the historical link between undirected basic research and the development of crucial medicines.
  • To emphasize the delayed realization of therapeutic relevance in scientific exploration.

Main Methods:

  • Historical analysis of transformative medicines.
  • Review of the origins of fundamental scientific discoveries.

Main Results:

  • Transformative medicines often stem from research initially lacking therapeutic goals.

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  • The impact of basic science on medicine can take decades to emerge.

    • Conclusions:

    • Continued investment in fundamental research is vital for future medical breakthroughs.
    • Recognizing the long-term value of basic science is crucial for sustained therapeutic innovation.