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Updated: Feb 11, 2026

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
Published on: November 10, 2014
Clinical Implications of Transbronchial Biopsy for Surgically-resected Non-small Cell Lung Cancer
Motoaki Yasukawa1, Noriyoshi Sawabata2, Takeshi Kawaguchi2
1Department of Thoracic and Cardiovascular Surgery, Nara Medical University School of Medicine, Nara, Japan myasukawa@naramed-u.ac.jp.
Background/Aim:
Lung biopsies might cause metastasis and/or dissemination. The aim of this study was to review our institutional experience and analyze the outcomes of resection for non-small cell lung cancer (NSCLC), in patients who had received preoperative transbronchial biopsy using fiberoptic bronchoscopy with fluoroscopic imaging (BFS).
Patients And Methods:
The medical records of consecutive patients between 2010 and 2015 were retrospectively reviewed. Patients were divided into two groups (BFS and Non-BFS). Overall survival (OS) curves and recurrence-free survival (RFS) curves were plotted using the Kaplan-Meier method. Cox regression analyses were used to evaluate the hazard ratio (HR) with the endpoint OS or RFS.
Results:
We studied the medical records of 531 patients. The 5-year OS rate was 91.8% and 79.8%, in the BFS group and in the Non-BFS group, respectively (p<0.001). BFS was an independent factor associated with RFS HR=2.164 (95%CI=1.399-2.346).
Conclusion:
Preoperative BFS is a prognostic factor in patients receiving surgery for NSCLC.
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