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[Prediction of Bacterial and Archaeal Allergenicity with AllPred Program]
A O Bragin1,2, V S Sokolov1, P S Demenkov1
1Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090 Russia.
Molekuliarnaia Biologiia
|April 27, 2018
Summary
Computer programs like Allpred predict protein allergenicity. Allergenic proteins are more common in archaea, secreted proteins, highly expressed proteins, and pathogenic bacteria.
Area of Science:
- Bioinformatics
- Computational Biology
- Allergenicity Prediction
Background:
- Allergic disorders are a growing global health concern.
- Increased exposure to environmental allergens, including proteins, contributes to rising allergy rates.
- Predicting protein allergenicity is crucial for public health and requires advanced bioinformatics tools.
Purpose of the Study:
- To predict the allergenicity of proteins from 462 archaea and bacteria species using the Allpred program.
- To investigate the relationship between protein characteristics (origin, localization, expression) and allergenicity.
- To assess the potential allergenicity of proteins from pathogenic versus non-pathogenic microorganisms.
Main Methods:
- Utilized the Allpred program for protein allergenicity prediction.
- Analyzed complete genomes of 462 archaea and bacteria species.
- Segregated proteins based on organism type (archaea/bacteria), intracellular localization, and gene expression levels.
- Compared allergenicity predictions between pathogenic and non-pathogenic microorganisms.
Main Results:
- Allergenic proteins were predicted more frequently in archaea than in bacteria.
- Secreted proteins showed a higher prevalence of predicted allergenicity.
- A statistically significant correlation was found between high gene expression levels and increased protein allergenicity.
- Pathogenic microorganisms exhibited a significantly higher number of predicted allergens compared to non-pathogenic ones.
Conclusions:
- The Allpred program effectively predicts protein allergenicity across diverse microbial species.
- Protein localization, expression level, and organism type (archaea vs. bacteria) are key factors influencing allergenicity.
- Pathogenic bacteria and archaea represent a higher potential source of allergenic proteins, warranting further investigation.
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