Related Experiment Video

Updated: Feb 11, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

7.2K

Role of the NFκB-signaling pathway in cancer

Longzheng Xia1, Shiming Tan1, Yujuan Zhou1

  • 1Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, Hunan, China.

Oncotargets and Therapy
|April 27, 2018
PubMed

Insights

This review summarizes the critical role of the Nuclear Factor kappa B (NFκB) signaling pathway in cancer development and treatment. Understanding NFκB is key to advancing targeted cancer therapies and improving patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Signaling Pathways

Background:

  • Cancer involves uncontrolled cell growth, with current treatments facing limitations due to tumor-specific characteristics.
  • Aberrant signaling pathways are central to cancer pathogenesis, influencing tumor growth, progression, and relapse.
  • Targeted therapies focusing on oncogenic signaling pathways have shown promise in improving cancer patient outcomes.

Purpose of the Study:

  • To provide an updated review of the Nuclear Factor kappa B (NFκB) signaling pathway.
  • To highlight the involvement of NFκB in cancer pathogenesis and its potential as a therapeutic target.
  • To consolidate current understanding of NFκB's role in various cancers.

Main Methods:

  • Literature review of scientific publications on the NFκB signaling pathway in cancer.
  • Analysis of studies investigating the role of NFκB in tumor development and progression.
  • Synthesis of information regarding targeted therapies against NFκB effectors.

Main Results:

  • Excessive activation of the NFκB signaling pathway is a common feature in diverse tumor tissues.
  • NFκB plays a significant role in the growth, progression, and potential relapse of various cancers.
  • Targeting components of the NFκB pathway represents a promising strategy for novel cancer treatments.

Conclusions:

  • The NFκB signaling pathway is a crucial factor in cancer biology.
  • Targeting NFκB offers a potential avenue for more effective cancer therapies.
  • Further research into NFκB modulation is warranted for advancing cancer treatment modalities.
Keywords:
cancerinflammationnuclear factor kappa-Bp65signaling pathway

More Related Videos

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells13:38

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

12.7K
Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

20.7K

Related Concept Videos

Role of ER in the Secretory Pathway01:17

Role of ER in the Secretory Pathway

Eukaryotic cells have a special pathway that enables communication between various intracellular membrane-bound compartments and also with the extracellular environment. This pathway is termed as the secretory pathway.
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
7.2K
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.6K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
10.1K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.4K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.5K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
10.7K