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Updated: Feb 11, 2026

Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta
07:06

Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta

Published on: April 3, 2017

48.9K

Cardiac Restoration Stemming From the Placenta Tree: Insights From Fetal and Perinatal Cell Biology

Sveva Bollini1, Antonietta R Silini2, Asmita Banerjee3

  • 1Regenerative Medicine Laboratory, Department of Experimental Medicine, University of Genova, Genova, Italy.

Frontiers in Physiology
|April 27, 2018
PubMed

Insights

Fetal and perinatal stem cells offer promising avenues for cardiac repair and regeneration, addressing limitations of current treatments like heart transplantation. These cells show potential in various therapeutic strategies for heart failure.

Area of Science:

  • Regenerative Medicine
  • Cardiovascular Biology
  • Stem Cell Therapy

Background:

  • Cardiovascular diseases, including myocardial ischemia/infarction and cardiotoxicity, lead to heart failure.
  • Current treatments like heart transplantation are limited by donor availability.
  • Stem cell-based therapies are being explored for cardiac repair and regeneration.

Purpose of the Study:

  • To review the current state of fetal and perinatal stem cells for cardiac repair.
  • To discuss pathological conditions and therapeutic strategies for heart regeneration.

Main Methods:

  • Review of existing literature on fetal and perinatal stem cells.
  • Analysis of therapeutic approaches including cell transplantation, paracrine therapy, reprogramming, and tissue engineering.

Main Results:

  • Fetal and perinatal stem cells possess significant regenerative capacity and self-renewal capabilities.
  • These cells are easily collected from clinical waste materials like amniotic fluid and placenta.
  • Various therapeutic strategies are being investigated for their application in cardiac repair.

Conclusions:

  • Fetal and perinatal stem cells represent a promising source for developing novel cardiac regenerative therapies.
  • Further research into cell transplantation, paracrine effects, reprogramming, and tissue engineering holds potential for treating heart failure.

Keywords:
amniotic fluidcardiac repaircardiomyocytecardioprotectionimmunomodulationparacrine effectplacentaumbilical cord

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