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Bone Metabolism Disorder in Epileptic Children
MAaryam Nakhaee Moghadam1, Alireza Teimouri1, Ali Khajeh1
1Children & Adolescent Health Research Center, Resistant Tuberculosis Institute, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Insights
Epileptic children show higher rates of vitamin D deficiency and hyperparathyroidism compared to healthy children. This study highlights potential bone metabolism complications linked to epilepsy management in pediatric patients.
Area of Science:
- Pediatric Endocrinology
- Metabolic Bone Disease
- Clinical Neurology
Background:
- Epilepsy management frequently involves anti-epileptic drugs.
- These medications can potentially lead to complications affecting bone and vitamin D metabolism.
- Understanding these metabolic disturbances is crucial for comprehensive patient care.
Purpose of the Study:
- To compare bone metabolism disorders in epileptic children versus healthy children.
- To investigate the prevalence of vitamin D deficiency and parathyroid hormone abnormalities.
- To assess potential links between anti-epileptic drug use and metabolic bone complications.
Main Methods:
- A case-control study conducted in Zahedan, Iran (2014-2015).
- Enrolled 40 epileptic children and 40 age-matched healthy controls.
- Assessed serum levels of calcium, phosphorus, parathyroid hormone, magnesium, vitamin D, albumin, and urine creatinine.
Main Results:
- Epileptic children exhibited a significantly higher prevalence of low vitamin D levels (37.5% vs. 12.5%, P=0.010).
- Abnormal parathyroid hormone (PTH) levels were more frequent in epileptic children (13 vs. 2, P=0.002).
- Serum calcium and magnesium levels were comparable between groups; medication count did not impact metabolic parameters.
Conclusions:
- Epileptic children have an increased frequency of hyperparathyroidism and vitamin D deficiency.
- These findings underscore the importance of monitoring bone metabolism in children with epilepsy.
- Further research is warranted to explore preventative strategies against these complications.
Objective:
There are frequent anti-epileptic drugs used in management of epilepsy. Anti-epileptic drugs may have some complications on bone and vitamin D metabolism. This study aimed to comparison the bone metabolism disorder in epileptic children with healthy child in Zahedan, eastern Iran from Jul 2014 to Jun 2015.
Materials & Methods:
This case-control study was performed on bone metabolism disorder in epileptic children between 2014-2015. Forty epileptic children were enrolled based on accessibility scheme and 40 participants randomly selected for control group from those referred to the pediatric ward and clinic of Ali Ebn Abi Talib Hospital and Ali Asghar Clinic in Zahedan City, Sistan & Baluchestan Province, eastern Iran. Blood samples were collected from all participants to assess serum calcium, phosphorus, parathyroid hormone, magnesium, vitamin D, serum albumin, creatinine random urine.
Results:
Of 40 epileptic children, 23 (57.5%) and 17 (42.5%) were male and female respectively, The prevalence of lower mean vitamin D levels was 37.5% for patients compared to 12.5% for controls (chi-square=6.667 and P=0.010). Of 80 participants, 15 individuals had abnormal PTH levels detected of 2 and 13 for patients and control groups, respectively (chi-square =9.928 and P=0.002). Serum calcium and magnesium levels were comparable in both groups. The status of the parameters in the classification of normal and abnormal assessed based on number of medications intake resulted that number of medications intake had no effect on the status of the parameter.
Conclusion:
The frequency of hyperparathyroidism and vitamin D deficiency is increased in epileptic children.
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