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Comparison of efficacy and tolerance between combination therapy and monotherapy as first-line chemotherapy in

Keun-Wook Lee1, Dae Young Zang2, Min-Hee Ryu3

  • 1Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea.

Contemporary Clinical Trials Communications
|April 27, 2018
PubMed
Abstract

Keywords:
5-FU, 5-fluorouracilADL, activities of daily livingAGC, advanced gastric cancerAST/ALT, aspartate aminotransferase/alanine aminotransferaseCCr, creatinine clearanceCGA, comprehensive geriatric assessmentCI, confidence intervalCRF, case report formCT, computed tomographyChemotherapyDSMB, data safety monitoring boardECOG, Eastern Cooperative Oncology GroupEORTC QLQ-C30, European Organization for Research and Treatment of Cancer core quality of life questionnaireEORTC QLQ-STO22, European Organization for Research and Treatment of Cancer quality of life questionnaire-gastricElderlyFAS, full analysis setGastric cancerHER-2, human epidermal growth factor receptor-2HR, hazard ratioIADL, independent activities of daily livingIIT, intent to treatKCSG, Korean Cancer Study GroupKG-7, Korean Cancer Study Group geriatric toolKPS, Karnofsky performance statusNCI CTCAE, National Cancer Institute Common Terminology Criteria for Adverse EventsOS, overall survivalPFS, progression-free survivalPPS, per-protocol setPS, performance statusQoL, quality of lifeRCT, randomized controlled trialRECIST, Response Evaluation Criteria in Solid TumorsRR, response rateRandomized controlled trialSAE, serious adverse eventSEER, Surveillance, Epidemiology, and End ResultsUNL, upper normal limit

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