Related Experiment Video

Updated: Feb 11, 2026

Modified Laparoscopic Anatomic Hepatectomy: Two-Surgeon Technique Combined with the Simple Extracorporeal Pringle Maneuver
12:27

Modified Laparoscopic Anatomic Hepatectomy: Two-Surgeon Technique Combined with the Simple Extracorporeal Pringle Maneuver

Published on: June 16, 2023

3.8K

Does Intermittent Pringle Maneuver Increase Postoperative Complications After Hepatectomy for Hepatocellular

Kit Fai Lee1, John Wong2, Sunny Y S Cheung2

  • 1Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32, Ngan Shing Street, Shatin, N.T., Hong Kong SAR, China. leekf@surgery.cuhk.edu.hk.

World Journal of Surgery
|April 27, 2018
PubMed
Abstract

Insights

Intermittent Pringle maneuver (IPM) during hepatectomy for hepatocellular carcinoma (HCC) did not increase overall postoperative complications. However, IPM was linked to higher rates of subclinical ascites and pleural effusion in HCC patients.

Area of Science:

  • Hepatobiliary Surgery
  • Surgical Oncology
  • Gastroenterology

Background:

  • Previous research suggested intermittent Pringle maneuver (IPM) may increase postoperative complications after hepatectomy.
  • Potential complications linked to IPM include ascites, pleural effusion, wound infection, and intra-abdominal collection.

Purpose of the Study:

  • To evaluate the hypothesis that IPM during hepatectomy for hepatocellular carcinoma (HCC) increases postoperative complications.
  • To compare complication rates between patients undergoing IPM and those with no Pringle maneuver (NPM).

Main Methods:

  • A randomized controlled trial involving patients undergoing elective open hepatectomy for HCC.
  • Patients were randomized to either IPM or NPM groups.
  • Postoperative complications, including radiological ascites, pleural effusion, and intra-abdominal collection, were monitored using ultrasound and chest X-ray.

Main Results:

  • Fifty patients in the IPM group and 50 in the NPM group were analyzed; demographics and operative parameters were comparable.
  • Overall postoperative complication rates were similar between IPM (36.0%) and NPM (28.0%) groups (P=0.391).
  • The IPM group showed significantly higher rates of radiological posthepatectomy ascites (42.0% vs. 22.0%, P=0.032) and pleural effusion (66.0% vs. 38.0%, P=0.005).

Conclusions:

  • The study did not detect a significant difference in overall postoperative complications between IPM and NPM during HCC hepatectomy.
  • However, IPM use was associated with an increased incidence of subclinical ascites and pleural effusion.
  • Further investigation may be warranted to understand the implications of these subclinical findings.

More Related Videos

Laparoscopic Anterior Right Hepatectomy: A Single-Center Experience09:51

Laparoscopic Anterior Right Hepatectomy: A Single-Center Experience

Published on: December 4, 2023

1.7K
Application of Hemostatic Devices in Laparoscopic Hepatectomy04:23

Application of Hemostatic Devices in Laparoscopic Hepatectomy

Published on: April 19, 2022

2.9K

Related Concept Videos

Trial and Error and Algorithm01:12

Trial and Error and Algorithm

A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
429
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.0K
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.9K
Increasing Function01:18

Increasing Function

An increasing function exhibits a rise in output values as input values increase. This behavior is depicted graphically as a curve or line that slopes upward from left to right. Such a function satisfies the condition that if x1 < x2, then f(x1) < f(x2), indicating that the function values grow with increasing inputs. This concept is fundamental in understanding growth trends across various domains, such as population dynamics, financial investments, or resource consumption.The...
401
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
954
Random Error01:04

Random Error

Random or indeterminate errors originate from various uncontrollable variables, such as variations in environmental conditions, instrument imperfections, or the inherent variability of the phenomena being measured. Usually, these errors cannot be predicted, estimated, or characterized because their direction and magnitude often vary in magnitude and direction even during consecutive measurements. As a result, they are difficult to eliminate. However, the aggregate effect of these errors can be...
9.8K