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Published on: December 20, 2016
New trends and applications in cyanation isotope chemistry
1R&D, Integrated Drug Discovery, Isotope Chemistry and Metabolite Synthesis, Sanofi Germany, Frankfurt/Main, Germany.
Abstract:
In this review, newly developed cyanation methods are evaluated in regards to their usefulness in synthetic isotope chemistry. In combination with already established protocols in 13/14 C- or 11 C-isotope chemistry, this manuscript should help isotope scientists to choose the best possible method for their scientific cyanation problem, but with the main focus on 14 C-applications. Perhaps, most promising of the described novel cyanation reaction is the decarboxylation-cyanation-hydrolysis approach which makes a 1-step late-stage functionalization procedure possible.
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