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Cough caused by cilazapril.

E B Lernhardt1, M G Ziegler

  • 1Department of Medicine, UCSD Medical Center 92103.

The American Journal of the Medical Sciences
|August 1, 1988
PubMed
Summary
This summary is machine-generated.

A chronic cough is a frequent side effect of Angiotensin-converting enzyme (ACE) inhibitors, affecting over a third of patients in one study. This challenges the perception of cough as a rare adverse event for these hypertension and heart failure medications.

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Area of Science:

  • Pharmacology
  • Cardiovascular Medicine

Background:

  • Angiotensin-converting enzyme (ACE) inhibitors are widely prescribed for hypertension and congestive heart failure.
  • A dry cough is a known, though often considered rare, side effect of ACE inhibitor therapy.

Purpose of the Study:

  • To investigate the incidence of chronic cough in patients treated with the investigational ACE inhibitor, cilazapril.

Main Methods:

  • A clinical observation of 30 patients receiving cilazapril.
  • Patient-reported complaints of chronic cough were systematically recorded.

Main Results:

  • Eleven out of 30 patients (approximately 36.7%) reported a chronic cough while on cilazapril treatment.
  • This incidence suggests a higher frequency than typically reported for ACE inhibitor-induced cough.

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Conclusions:

  • Chronic cough may be a more common adverse effect of Angiotensin-converting enzyme (ACE) inhibitors than previously recognized.
  • Further research is warranted to understand the prevalence and mechanisms of this side effect.