Related Experiment Video
Updated: Feb 11, 2026

Measuring and Modeling Contractile Drying in Human Stratum Corneum
Published on: March 1, 2017
Using Stratum Corneum Thickness and Configuration to Distinguish Lichenoid Dermatoses
1Department of Dermatology, UCSD, La Jolla, San Diego, CA.
Background:
Clues in the stratum corneum (SC) can aide in histopathologic diagnosis of many conditions.
Objective:
To determine if SC configuration and thickness could help differentiate the lichenoid dermatoses.
Methods:
A retrospective study was performed. A total of 305 cases (55 lichenoid keratosis, 51 lichen planus, 7 hypertrophic lichen planus, 40 lichenoid drug eruption, 19 lichenoid graft-vs.-host disease, 14 hypertrophic lupus, 46 lichenoid actinic keratosis, 73 lentigo maligna) fulfilled the selection criteria. Cases were digitally scanned using the 40× (0.23 μm/pixel) mode of a Hamamatsu NanoZoomer 2.0-HT Slide Scanner (Hamamatsu Photonics, Hamamatsu City, Japan), allowing for the creation of virtual (digital) slides. SC thicknesses and configuration were assessed for each case.
Results:
Mixed SC patterns were common in cases of lichenoid keratoses. Compact parakeratosis was the most common pattern in lichenoid drug eruption. Tiered parakeratosis was the most predominant pattern in cases of lichenoid graft versus host disease and lichenoid actinic keratosis. Hypertrophic lupus had the highest average SC thickness.
Limitations:
The sample size for cases of hypertrophic lupus and hypertrophic lichen planus was low.
Conclusions:
SC thickness and configuration can be utilized to help differentiate the lichenoid dermatoses.
Related Concept Videos
Controller Configurations
Control-system compensation involves various configurations, most commonly series or cascade compensation, in which the controller...
Electron Configurations
The relative energies of the subshells determine the order in which atomic orbitals are filled (1s, 2s, 2p, 3s, 3p,...
Electron Configuration of Multielectron Atoms
Configurations of BJT
The common base configuration is noted for its high voltage gain, positioning it as an ideal choice for single-stage amplifier circuits, such as microphone pre-amplifiers. A notable...
Stability of Equilibrium Configuration
A stable equilibrium occurs when a system tends to return to its original position when given a small displacement, and the potential energy is at its minimum. An example of a stable equilibrium is when a cantilever beam is fixed at one end and a weight is attached to the other end. If the weight...
Stability of Equilibrium Configuration: Problem Solving
Problem-solving in the context of the stability of equilibrium configuration...

