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Bariatric surgery and gene expression in the gut
Priscila Sala1,2, M L Corrêa-Giannella2,3, Dan L Waitzberg1
1Departamento de Gastroenterologia, Laboratorio Metanutri (LIM 35), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Current Opinion in Clinical Nutrition and Metabolic Care
|April 27, 2018
Summary
Bariatric surgery alters gut gene expression, impacting glucose metabolism and nutrient absorption. This review highlights how these changes may contribute to vitamin B12 deficiency post-surgery.
Area of Science:
- Genomics
- Gastroenterology
- Metabolic Surgery
Background:
- Bariatric surgery is a primary intervention for severe obesity, leading to significant weight loss and comorbidity reduction.
- Post-surgical adaptive gut responses involve significant changes in intestinal gene expression.
- Understanding these molecular alterations is crucial for managing patient outcomes.
Purpose of the Study:
- To review recent literature on bariatric surgery's impact on gut gene expression.
- To explore novel findings concerning genetic pathway modulation after bariatric procedures.
- To synthesize current knowledge on the relationship between surgical gut modifications and gene expression.
Main Methods:
- Literature review of experimental and clinical studies.
- Analysis of findings on intestinal gene expression changes post-bariatric surgery.
- Focus on genes related to glucose metabolism, nutrient transport, and vitamin B12 metabolism.
Main Results:
- Bariatric surgery demonstrably modulates intestinal gene expression.
- Changes in genes involved in glucose metabolism are consistently observed.
- Expression of genes for nutrient transporters and vitamin B12 metabolism is also affected, potentially leading to deficiency.
Conclusions:
- Bariatric surgery induces significant nutritional genomic changes.
- Altered gene expression pathways may explain postoperative complications like vitamin B12 deficiency.
- Further research into these molecular pathways can optimize obesity and comorbidity management.
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