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Updated: Feb 11, 2026
09:41
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
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Daily Temporal Associations Between Physical Activity and Symptoms in Multiple Sclerosis
Anna L Kratz1, Nora E Fritz2, Tiffany J Braley3
1Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI.
Summary
Physical activity and symptoms like fatigue and mood fluctuate together daily in multiple sclerosis (MS). Increasing physical activity in MS requires understanding this dynamic relationship.
Area of Science:
- Neurology
- Rehabilitation Science
- Behavioral Medicine
Background:
- Symptom severity is negatively associated with physical activity in multiple sclerosis (MS).
- The day-to-day correlation between physical activity and symptoms in individuals with MS remains unclear.
Purpose of the Study:
- To determine the temporal within-person associations of pain, fatigue, depressed mood, and perceived cognitive function with physical activity in MS.
Main Methods:
- Ambulatory adults with MS (N=107) underwent 7 days of home monitoring.
- Continuous physical activity data (wrist-worn accelerometer) and ecological momentary assessment (5x/day) of symptoms were collected.
- Multilevel mixed modeling was used for data analysis.
Main Results:
- Fatigue and depressed mood showed bidirectional associations with physical activity.
- Increased fatigue and depressed mood preceded decreased physical activity.
- Increased physical activity subsequently reduced fatigue and depressed mood, though the fatigue association varied by time of day.
Conclusions:
- Physical activity and symptoms (fatigue, mood) are dynamically related on a moment-to-moment basis in MS.
- Interventions to boost physical activity in MS should address the interplay between symptoms and activity levels.
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