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Updated: Feb 11, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
CD3 immunohistochemistry is helpful in the diagnosis of giant cell arteritis
Francesco Ciccia1, Angelo Ferrante1, Giuliana Guggino1
1Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Reumatologia, Università degli studi di Palermo, Palermo, Italy.
Objective:
To evaluate whether CD3 staining performed routinely on temporal artery biopsy specimens might improve the sensitivity of temporal artery biopsy in patients with biopsy-negative GCA.
Methods:
Two hundred and seventy biopsies were considered for this study, stained with haematoxylin and eosin and with an anti-CD3 antibody.
Results:
The addition of CD3 staining modified the sensibility and the specificity of the histologic examination in 89.47 and 95.00%, respectively, with a positive and negative predictive values of 97.00 and 79.78% .
Conclusion:
The addition of CD3 immunostaining to the classic histologic evaluation is accompanied by a significant increase in the sensibility with a comparable specificity.
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