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Atrial natriuretic factor inhibits norepinephrine release in an adrenergic clonal cell line (PC12)
J Drewett1, G Marchand, R Ziegler
1Department of Pharmacology, School of Medicine, University of Minnesota, Duluth 55812.
European Journal of Pharmacology
|May 20, 1988
Abstract:
Evidence for a presynaptic neuromodulatory effect of atrial natriuretic factor (ANF) has been obtained in rat adrenal pheochromocytoma cells (PC12), a clonal line that differentiates into adrenergic neuron-like cells when treated with nerve growth factor. ANF had no effect on basal norepinephrine (NE) release. In contrast, ANF markedly and significantly inhibited carbachol-induced NE release in a concentration-dependent manner. This result is consistent with the hypothesis that ANF may be an inhibitory neuromodulator.