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Antiandrogens and hirsutism.

P Biffignandi1, G M Molinatti

  • 1Istituto di Medicina Interna, Università degli Studi di Torino, Italia.

Hormone Research
|January 1, 1987
PubMed
Summary
This summary is machine-generated.

Female idiopathic hirsutism is treated with antiandrogen drugs like cyproterone acetate and spironolactone. These medications compete with dihydrotestosterone, offering effective clinical results for patients.

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Area of Science:

  • Endocrinology
  • Dermatology

Background:

  • Female idiopathic hirsutism presents with clinical manifestations and complex pathophysiological aspects.
  • Current therapeutic strategies primarily involve antiandrogen medications.

Purpose of the Study:

  • To discuss the clinical appearance, pathophysiology, and antiandrogen drug therapies for female idiopathic hirsutism.
  • To evaluate the efficacy of existing antiandrogen treatments.

Main Methods:

  • Review of clinical and pharmacological data on hirsutism treatment.
  • Discussion of antiandrogen compounds: cyproterone acetate and spironolactone.
  • Analysis of their mechanism of action, particularly competitive inhibition of dihydrotestosterone.

Main Results:

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  • Cyproterone acetate and spironolactone have demonstrated excellent clinical results in managing hirsutism.
  • Both compounds effectively compete with dihydrotestosterone at the skin androgen receptors.
  • Established regimens include reverse sequential therapy with cyproterone acetate and spironolactone, often combined with oral contraceptives.

Conclusions:

  • Antiandrogen therapies, specifically cyproterone acetate and spironolactone, are effective for female idiopathic hirsutism.
  • Their shared mechanism of competing with dihydrotestosterone underpins their long-standing clinical success.
  • Topical antiandrogen therapy represents a potential future advancement for patient benefit.