Red blood cells aggregability measurement of coagulating blood in extracorporeal circulation system with multiple-frequency electrical impedance spectroscopy
Related Experiment Video
Updated: Feb 11, 2026

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
Published on: January 12, 2018
Jianping Li1, Achyut Sapkota2, Daisuke Kikuchi3
1Institute of Precision Machinery, Zhejiang Normal University, Jinhua 321004, Zhejiang Province, China; Graduate School of Mechanical Engineering, Division of Artificial System Science, Chiba University, 1-33 Yayoi, Inage, Chiba 263-8522 Japan.
Abstract:
Red blood cells (RBCs) aggregability AG of coagulating blood in extracorporeal circulation system has been investigated under the condition of pulsatile flow. Relaxation frequency fc from the multiple-frequency electrical impedance spectroscopy is utilized to obtain RBCs aggregability AG. Compared with other methods, the proposed multiple-frequency electrical impedance method is much easier to obtain non-invasive measurement with high speed and good penetrability performance in biology tissues. Experimental results show that, RBCs aggregability AG in coagulating blood falls down with the thrombus formation while that in non-coagulation blood almost keeps the same value, which has a great agreement with the activated clotting time (ACT) fibrinogen concertation (Fbg) tests. Modified Hanai formula is proposed to quantitatively analyze the influence of RBCs aggregation on multiple-frequency electrical impedance measurement. The reduction of RBCs aggregability AG is associated with blood coagulation reaction, which indicates the feasibility of the high speed, compact and cheap on-line thrombus measurement biosensors in extracorporeal circulation systems.
Related Concept Videos
Measurement of Blood Pressure
Equipments Used To Measure Blood Pressure
This invasive approach involves cannulating a peripheral artery. During each cardiac contraction, pressure generates mechanical motion within the catheter, transmitted through rigid, fluid-filled tubing to a transducer. This transducer converts mechanical motion into electrical signals displayed as waveforms on a monitor. An automatic flushing system prevents blood backflow. Due to the potential risk of unexpected arterial blood loss, this method is primarily used in intensive...
Special considerations while measuring blood pressure
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
Composition of Blood
Formed elements constitute the remaining 45% of the blood volume. These...
Blood Flow
Blood Types
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...

