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Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
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Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
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Combinational strategy for high-performance cancer chemotherapy.

Si-Yong Qin1, Yin-Jia Cheng1, Qi Lei2

  • 1School of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan, 430074, China.

Biomaterials
|April 27, 2018
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Summary

Conventional cancer chemotherapy often fails due to tumor resistance. This review explores advanced combination therapies, including chemotherapy combined with gene, photo, or immunotherapy, to improve treatment outcomes.

Keywords:
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Area of Science:

  • Oncology
  • Cancer Therapeutics
  • Molecular Biology

Background:

  • Conventional single-drug chemotherapy (mono-chemotherapy) for cancer yields unsatisfactory clinical outcomes.
  • Tumor heterogeneity and drug resistance are significant challenges in current cancer treatment.
  • Advances in understanding cancer pathways necessitate novel therapeutic strategies.

Purpose of the Study:

  • To review recent progress in combination cancer therapies.
  • To explore the rationale behind combining different therapeutic modalities.
  • To provide guidelines for enhanced cancer treatment strategies.

Main Methods:

  • Literature review of recent advances in cancer combination therapy.
  • Analysis of chemotherapy combined with gene therapy, phototherapy, and immunotherapy.
  • Presentation of chemotherapy-involved multiple therapy approaches.

Main Results:

  • Combination therapies show promise in overcoming limitations of mono-chemotherapy.
  • Integrating various modalities, including chemotherapy, gene therapy, phototherapy, and immunotherapy, offers synergistic effects.
  • Chemotherapy-involved multiple therapy merges diverse treatment approaches for optimized outcomes.

Conclusions:

  • Combination strategies are crucial for improving cancer treatment efficacy.
  • Understanding molecular pathways guides the development of rational combination therapies.
  • These approaches may offer new guidelines for high-performance cancer treatments.