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[Association between high-sensitivity C-reactive protein and both cardiovascular, total mortality events in
1Division of Prevention and Community Health, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 102308, China.
Insights
High-sensitivity C-reactive protein (hs-CRP) is a significant predictor of cardiovascular events and mortality. Elevated hs-CRP levels are associated with increased risks, highlighting its importance in cardiovascular risk assessment.
Area of Science:
- Biochemistry
- Cardiology
- Epidemiology
Background:
- Cardiovascular diseases (CVD) remain a leading cause of mortality globally.
- Biomarkers for CVD risk stratification are crucial for early intervention.
- High-sensitivity C-reactive protein (hs-CRP) is an inflammatory marker with potential prognostic value.
Purpose of the Study:
- To investigate the association between hs-CRP levels and the risk of cardiovascular events.
- To determine the relationship between hs-CRP levels and all-cause mortality.
- To evaluate hs-CRP as an independent predictor of adverse cardiovascular and mortality outcomes.
Main Methods:
- A cohort of 5,984 participants aged 35-64 years was analyzed.
- hs-CRP levels were measured, and participants were categorized into three groups (<1 mg/L, 1-3 mg/L, >3 mg/L).
- Cox proportional hazards regression was used to assess the association with cardiovascular events and all-cause mortality after adjusting for confounders.
Main Results:
- Higher hs-CRP levels were associated with increased incidence rates of cardiovascular disease events and all-cause mortality.
- After adjustment, hazard ratios for cardiovascular events were 1.33 (1-3 mg/L) and 1.76 (>3 mg/L) compared to <1 mg/L (P=0.003).
- Hazard ratios for all-cause mortality were 1.76 (1-3 mg/L) and 2.64 (>3 mg/L) compared to <1 mg/L (P<0.001).
Conclusions:
- hs-CRP is an independent predictor of cardiovascular events.
- Elevated hs-CRP levels are significantly associated with an increased risk of all-cause mortality.
- hs-CRP measurement can enhance cardiovascular risk assessment.
Abstract:
Objective: To estimate the association between high-sensitivity C-reactive protein (hs-CRP) and cardiovascular events as well as all-cause mortality events. Methods: During 2009- 2010, out of the 11 623 individuals, 1 000 participants aged 35-64 years, were recruited and divided into 12 age-groups, to have received a study on CVD risk factors. Information on the risk factors of cardiovascular diseases was also collected. Fasting blood sample was gathered for all the participants, with hs-CRP tested. Participants in 7 out of the 12 sites were followed, with 6.21 years (36 075 person-years) as the median follow-up period. Cardiovascular and all-cause mortality events were collected. A total of 6 177 participants had been followed after excluding participants who had baseline infections, or did not take hs-CRP test/physical examination at the baseline. Finally, 5 984 participants were included for analysis. Participants were categorized into three groups based on the hs-CRP (mg/L) values: <1, 1-3 and >3, respectively. Cox proportional hazards regression model was used to analyze the relationships between hs-CRP with cardiovascular events or all-cause mortality events, after adjusting for confounding factors. Results: Mean age of the participants was 50.2 years. The incidence rates of cardiovascular disease events were 3.6/1 000 person-years, 7.1/1 000 person-years,and 10.4/1 000 person-years among three groups and 3.0/1 000 person-years, 5.7/1 000 person-years, 9.1/1 000 person-years for all-cause mortality events, respectively. After adjusting for confounding factors, the hazard risks (HR) for cardiovascular events were 1.33 (95%CI: 0.95-1.84) in the hs-CRP 1-3 mg/L group and 1.76 (95%CI: 1.20-2.60) in the hs-CRP>3 mg/L group when comparing with the hs-CRP<1 mg/L group (trend test P=0.003). The HRs for all-cause mortality events were 1.76 (95%CI: 1.23-2.54) and 2.64 (95%CI: 1.74-4.01) (trend test P<0.001), respectively. Conclusion: Hs-CRP appeared an independent predictor for cardiovascular events and all-cause mortality events.
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