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The function of bone morphogenetic proteins in the human ovary
Osamu Yoshino1,2, Jia Shi1, Yutaka Osuga1
1Department of Obstetrics and Gynecology University of Tokyo 7-3-1 Hongo, Bunkyo-ku 113-8655 Tokyo Japan.
Reproductive Medicine and Biology
|April 28, 2018
Summary
Bone morphogenetic proteins (BMPs) regulate early ovarian follicular growth, independent of gonadotropins (FSH/LH). BMPs induce and later suppress gonadotropin systems, ensuring proper follicle development and preventing premature maturation.
Area of Science:
- Reproductive Biology
- Endocrinology
- Ovarian Physiology
Background:
- Follicular growth initiation is independent of gonadotropins (FSH/LH) as their receptors appear late.
- Bone morphogenetic proteins (BMPs) are key intra-ovarian factors regulating early follicular development.
Purpose of the Study:
- To elucidate the interplay between the BMP and gonadotropin systems in ovarian physiology.
- To understand the role of BMPs in early follicular growth and maturation.
Main Methods:
- The abstract does not specify methods, focusing on the conceptual framework and existing literature.
- Literature review and synthesis of current understanding on BMP and gonadotropin signaling in the ovary.
Main Results:
- BMPs modulate gonadotropin receptors, inducing the gonadotropin system in early follicles.
- BMPs prevent premature follicular maturation by suppressing luteinization.
- The preovulatory LH surge eliminates BMPs, allowing luteinization to proceed.
Conclusions:
- The BMP and gonadotropin systems cooperate to regulate follicular development, maturation, and luteinization.
- BMPs are crucial for coordinating early follicular growth with later gonadotropin-dependent maturation.
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