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Related Concept Videos

Infertility in Males01:23

Infertility in Males

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Infertility in Females01:28

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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
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Adult Stem Cells01:33

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Disorders of the Male Reproductive System01:20

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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
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Stem cell research for male infertility.

Hideyuki Kobayashi1, Koichi Nagao1, Koichi Nakajima1

  • 1Department of Urology Toho University School of Medicine 6-11-1 Omori-Nishi, Ota-ku 143-8541 Tokyo Japan.

Reproductive Medicine and Biology
|April 28, 2018
PubMed
Summary

Stem cell research shows promise for treating male infertility. Scientists have generated stem cells with embryonic stem (ES)-like properties from adult human testis tissue, potentially leading to future therapies.

Keywords:
ES cellsSpermatogonial stem cellsStem cellsTestisiPS cells

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Area of Science:

  • Reproductive biology and stem cell science.

Background:

  • Stem cells possess self-renewal and differentiation capabilities, making them valuable for regenerative medicine.
  • Embryonic stem (ES) cells are well-researched, with growing interest in alternatives like induced pluripotent stem cells and adult stem cells.

Purpose of the Study:

  • To review stem cell research applications for treating male infertility.
  • To highlight advancements in generating stem cells from adult human testis tissue.

Main Methods:

  • Review of current stem cell research literature.
  • Focus on studies involving stem cells with potential for male infertility treatment.

Main Results:

  • Stem cells exhibiting embryonic stem (ES)-like properties have been successfully generated from adult human testis tissue.
  • This research contributes to understanding the potential of stem cells in reproductive medicine.

Conclusions:

  • Stem cell research is advancing our understanding of male infertility.
  • Future breakthroughs are anticipated to yield novel treatments for male infertility.