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Related Experiment Video

Updated: Feb 11, 2026

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Abnormal lysine acetylation with postovulatory oocyte aging.

Ah Reum Lee1, Le Thanh Ha1, Satoshi Kishigami1,2

  • 1Division of Biological Science, Graduate School of Biology-Oriented Science and Technology Kinki University 649-6493 Kinokawa Wakayama Japan.

Reproductive Medicine and Biology
|April 28, 2018
PubMed
Summary

Oocyte aging, a decline in developmental potential, is linked to epigenetic changes like histone acetylation. This review highlights how altered protein acetylation contributes to oocyte aging phenotypes.

Keywords:
HDACLysine acetylationMouseOocytePostovulatory in vitro aging

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Area of Science:

  • Reproductive biology
  • Epigenetics
  • Cellular aging

Background:

  • Postovulatory mammalian oocyte aging reduces developmental potential.
  • The precise mechanisms of oocyte aging remain largely unknown.
  • Epigenetic alterations, including histone acetylation, are implicated in oocyte aging.

Purpose of the Study:

  • To review the role of epigenetic alterations in oocyte aging.
  • To focus specifically on lysine acetylation in the context of oocyte aging.

Main Methods:

  • Literature search utilizing PubMed.
  • Inclusion of recent published data.

Main Results:

  • Histone acetylation increases in aging mouse oocytes, potentially affecting embryonic gene regulation.
  • Oocyte aging involves increased alpha-tubulin acetylation.
  • Nicotinamide, a class III HDAC inhibitor, partially mitigates some oocyte aging phenotypes.

Conclusions:

  • Aberrant protein acetylation regulation is suggested in oocyte aging.
  • Dysregulated acetylation may contribute to observed oocyte aging phenotypes.