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Updated: Feb 11, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
New perspectives: systems medicine in cardiovascular disease
Frank Kramer1, Steffen Just2, Tanja Zeller3,4
1Department of Medical Statistics, University Medical Center Göttingen, Humboldtallee, 32, Göttingen, Germany.
Background:
Cardiovascular diseases (CVD) represent one of the most important causes of morbidity and mortality worldwide. Innovative approaches to increase the understanding of the underpinnings of CVD promise to enhance CVD risk assessment and might pave the way to tailored therapies. Within the last years, systems medicine has emerged as a novel tool to study the genetic, molecular and physiological interactions.
Conclusion:
In this review, we provide an overview of the current molecular-experimental, epidemiological and bioinformatical tools applied in systems medicine in the cardiovascular field. We will discuss the status and challenges in implementing interdisciplinary systems medicine approaches in CVD.
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