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Related Experiment Video

Updated: Feb 11, 2026

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
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Foetoplacental epigenetic changes associated with maternal metabolic dysfunction.

Bredford Kerr1, Andrea Leiva2, Marcelo Farías2

  • 1Laboratory of Biology, Centro de Estudios Científicos (CECs), Valdivia 5110466, Chile.

Placenta
|April 28, 2018
PubMed
Summary

Maternal metabolic conditions during pregnancy, such as obesity or diabetes, can epigenetically program offspring for adult metabolic diseases. Understanding these fetal programming changes is key to preventing future health issues.

Keywords:
Endothelial dysfunctionEpigeneticPlacentaProgrammingVasculature

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Area of Science:

  • Reproductive biology
  • Metabolic disease research
  • Developmental programming

Background:

  • Sedentary lifestyles and poor eating habits contribute to metabolic diseases.
  • Pregnancy is a critical period for health programming, influencing adult disease risk.
  • The fetal environment significantly impacts long-term health outcomes.

Purpose of the Study:

  • To review the role of the fetal environment in programming adult metabolic disorders.
  • To highlight the impact of maternal metabolic conditions on offspring health.
  • To explore epigenetic mechanisms in fetal programming.

Main Methods:

  • Literature review focusing on maternal metabolic health and offspring outcomes.
  • Analysis of epigenetic modifications, specifically CpG methylation.
  • Examination of gene expression in metabolism-related genes within the placenta and offspring tissues.

Main Results:

  • Maternal dyslipidemia, obesity, and gestational diabetes mellitus predispose offspring to adult metabolic alterations.
  • Epigenetic modifications, such as altered CpG methylation, affect metabolism-related genes.
  • These changes impact nutrient transfer and macromolecule transport from mother to fetus.

Conclusions:

  • The maternal environment during pregnancy is crucial for programming fetal development and long-term health.
  • Epigenetic alterations in metabolism-related genes are a key mechanism linking maternal metabolic state to offspring disease risk.
  • Understanding these mechanisms is vital for preventing adult metabolic disorders originating from adverse pregnancy conditions.