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Atherosclerosis and clonal hematopoyesis: A new risk factor

José A Páramo Fernández1

  • 1Servicio de Hematología y Hemoterapia, CUN, Laboratorio de Aterotrombosis CIMA, Universidad de Navarra, CIBERCV, Pamplona, España.

Clinica E Investigacion En Arteriosclerosis : Publicacion Oficial De La Sociedad Espanola De Arteriosclerosis
|April 28, 2018
PubMed

Recent research has revealed that clonal hematopoyesis of indeterminate potential (CHIP) characterized by the acquisition of somatic mutations in hematopoietic stem cells, is not only a common age-related disorder and a premalignant condition, but it is also associated with the development of atherosclerotic vascular diseases. Mutations in DNMT3A, TET2 and ASXL1 were each individually associated with coronary heart disease, stroke and coronary calcification. Therefore, CHIP emerges as a new risk factor for atherosclerotic vascular pathologies and its detection may be relevant as a new therapeutic target in order to modify the natural course of the disease.

Keywords:
AterosclerosisAtherosclerosisCalcificación coronariaCardiovascular diseasesClonal hematopoiesis of indeterminate potentialCoronary calcificationEnfermedades cardiovascularesHematopoyesis clonal de potencial indeterminado

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