Prospective Evaluation of Self-Reported Aggression in Transgender Persons

Area of Science:

• Endocrinology
• Psychology
• Gender Studies

Background:

• Existing guidelines suggest testosterone treatment may increase aggression in transgender men, despite inconclusive research.
• This study addresses the need for empirical evidence on testosterone's effects on aggression in transgender populations.

Purpose of the Study:

• To investigate the association between testosterone levels and aggression in transgender individuals seeking treatment.
• To explore the influence of mental health (anxiety, depression) and social support on aggression in this population.

Main Methods:

• A prospective study of 140 transgender individuals (men and women) undergoing gender-affirming hormonal therapy.
• Self-report measures assessed aggression (IIP-32), anxiety/depression (HADS), social support, and transphobia.
• Correlations were analyzed between aggression scores and hormonal levels, psychological factors, and psychosocial variables.

Main Results:

• No correlation was found between testosterone levels and self-reported aggression in transgender men.
• Aggression scores did not increase in transgender men on testosterone or decrease in transgender women on feminizing hormones.
• Increased anxiety scores correlated with higher aggression scores across all participants.
• Lower social support from friends correlated with higher aggression in transgender women.

Conclusions:

• Long-term testosterone administration in transgender men is not associated with increased aggressive behavior.
• Anxiety and social support appear to be significant factors influencing self-reported aggression in transgender individuals.
• Findings provide reassurance for physicians regarding the psychological safety of testosterone therapy in transgender men.