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Overview of the Cardiovascular System

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Related Experiment Video

Updated: Feb 11, 2026

Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry

Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry

Published on: June 9, 2019

Cardiovascular Metabolomics.

Robert W McGarrah^1,2,3, Scott B Crown¹, Guo-Fang Zhang^1,4,3

¹From the Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute (R.W.M., S.B.C., G.F.Z., S.H.S., C.B.N.).

Circulation Research

|April 28, 2018

Summary

This summary is machine-generated.

Metabolomics, a powerful technology, reveals critical metabolic changes in cardiovascular diseases like heart failure. This review explores advanced metabolomics techniques and their role in identifying new biomarkers for heart conditions.

Keywords:

amino acids cardiovascular diseases heart failure ketone bodies metabolism

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Last Updated: Feb 11, 2026

Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry

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Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS

Published on: March 14, 2013

Area of Science:

Biochemistry
Cardiovascular Medicine
Metabolomics

Background:

Cardiac metabolism disturbances are central to cardiovascular diseases.
Metabolomics offers a comprehensive approach to study these metabolic alterations.

Purpose of the Study:

To review the current state of metabolomics technologies for cardiovascular disease research.
To highlight advances in metabolomics for understanding heart failure and ischemic heart disease.

Main Methods:

Discussion of various metabolomics platforms and study design considerations.
Exploration of stable isotope-based metabolic flux analysis.
Review of recent literature on metabolomics applications in cardiovascular diseases.

Main Results:

Metabolomics has enhanced understanding of metabolic changes in heart failure and ischemic heart disease.
New biomarkers for cardiovascular diseases have been identified through metabolomics studies.
Metabolomics technologies are rapidly evolving.

Conclusions:

Metabolomics is a vital tool for investigating cardiac metabolism and cardiovascular diseases.
Continued technological advancements promise further insights into heart disease mechanisms and biomarkers.