Related Experiment Video
Updated: Feb 11, 2026

Visual and Microscopic Evaluation of Streptomyces Developmental Mutants
Published on: September 12, 2018
Cyclo(Pro-DOPA), a third identified bioactive metabolite produced by Streptomyces sp. 8812
Jolanta Solecka1, Aleksandra Rajnisz-Mateusiak2, Adam Guspiel2
1National Institute of Public Health-National Institute of Hygiene, Laboratory of Biologically Active Compounds, Warsaw, Poland. jsolecka@pzh.gov.pl.
Abstract:
A new metabolite, cyclic dipeptide, cis-(3S,8aS)-3-(3,4-dihydroxybenzyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, named JS-3 was isolated from Streptomyces sp. 8812 fermentation broth. Its chemical structure was established by means of spectroscopic analysis. A wide-range-screening study, which included inhibition assay of DD-carboxypeptidase/transpeptidase activity, determination of antibacterial, antifungal, and antiproliferative activities as well as free-radical scavenging was performed. To authors knowledge, this is the first isolation of such compound from natural sources and the first one from bacteria, Streptomyces.
Related Concept Videos
Identifying Statistically Significant Differences: The F-Test
Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug
Design Example: Identifying the Locations of Monuments in the Field Using Global Positioning System Device
Hybridization of Atomic Orbitals II
Hybridization of Atomic Orbitals I
Solubility Equilibria
The...

