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Leaf Spray Mass Spectrometry: A Rapid Ambient Ionization Technique to Directly Assess Metabolites from Plant Tissues
Published on: June 21, 2018
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Ambient desorption/ionization mass spectrometry: evolution from rapid qualitative screening to accurate
Jacob T Shelley1, Sunil P Badal2, Carsten Engelhard3
1Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY, 12180, USA. shellj@rpi.edu.
Analytical and Bioanalytical Chemistry
|April 28, 2018
Summary
This review covers recent advances in ambient desorption/ionization mass spectrometry (ADI-MS), focusing on quantitative analysis via direct sampling. Improving quantification accuracy is crucial for ADI-MS development and broader application.
Area of Science:
- Analytical Chemistry
- Mass Spectrometry
Background:
- Ambient desorption/ionization mass spectrometry (ADI-MS) enables direct, open-air sampling.
- Accurate quantification remains a challenge in ADI-MS, hindering its routine application.
Purpose of the Study:
- To review recent trends and developments in ADI-MS.
- To highlight the importance and progress in quantitative ADI-MS.
Main Methods:
- Review of novel sample introduction strategies for enhanced reproducibility.
- Discussion of tailored sample preparation protocols to mitigate matrix effects.
- Exploration of multimode ionization sources and quantitative mass spectrometry imaging.
Main Results:
- Several research groups are actively developing optimized ADI-MS approaches.
- Key trends focus on improving reproducibility and accuracy in quantitative analyses.
- Significant interest exists in quantitative mass spectrometry imaging using ADI-MS.
Conclusions:
- Advancements in ADI-MS are paving the way for more routine quantitative analyses.
- Continued development of sample handling and ionization techniques is essential.
- Quantitative mass spectrometry imaging is a promising area within ADI-MS.
Keywords:
ADI-MSAmbient mass spectrometryInternal standardMass spectrometry imagingMatrix effectsQuantificationMore Related Videos
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