Related Experiment Video
Updated: Feb 11, 2026

10:37
Ferric Chloride-induced Murine Thrombosis Models
Published on: September 5, 2016
23.2K
A case series: Association of anaphylaxis with a significant decrease in platelet levels and possible secondary risk
Brian P Peppers1, Anant Vatsayan2, Jignesh Dalal2
1Adult and Pediatric ACGME Osteopathic Recognized Allergy and Immunology Fellowship, University Hospitals, Cleveland Medical Center, Cleveland, Ohio.
Immunity, Inflammation and Disease
|April 28, 2018
Summary
Anaphylaxis may increase thrombosis risk due to platelet activation. This case series suggests a link between anaphylaxis, platelet changes, and blood clot formation, warranting further investigation.
Area of Science:
- Immunology
- Hematology
- Cardiovascular Medicine
Background:
- Anaphylaxis is a severe inflammatory response involving shared mediators with the coagulation cascade.
- Platelet-activating factor (PAF) is implicated in anaphylaxis, but its role in thrombosis risk is unclear.
- The function of platelets during and after anaphylaxis is not well understood.
Related Concept Videos
Decreasing Function
312
A decreasing function describes a relationship where the output consistently declines as the input increases. This means that for any two input values, if one is greater than the other, the corresponding output is smaller. Mathematically, a function f is decreasing on an interval I if for every x1 < x2 in I, f (x1) > f (x2). This type of behavior is visually identified on a graph that slopes downward from left to right.The nature of a function can be analyzed by calculating...
312
Secondary Active Transport
138.2K
One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme “pump” embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
138.2K
Decreased Body Temperature
1.1K
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
1.1K
Decreased pulse rate
933
Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...
933
Venous Thrombosis I: Introduction
485
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
485
Secondary Healthcare System
2.1K
Secondary healthcare is offered by a specialist, generally in hospitals or clinics for patients referred by primary healthcare providers. It occurs when a person has an illness or injury that requires specific medical care. Secondary care is often referred to as acute care. Secondary care can range from uncomplicated care to repair a minor laceration or treat a strep throat infection to more complicated emergent care, such as treating a head injury sustained in an automobile accident. Whatever...
2.1K

